Innovative products and technology transfer

1. A method to construct small superparamagnetic iron oxide nanoparticle of homogeneous size and the related increased efficiency for intracellular labeling with surface modification of amine peripheries:

Together with Prof. Ken C.-F. Leung at the Center of Novel Functional Molecules, The Chinese University of Hong Kong, and Prof. Ling Qin at the Department of Orthopedics and Traumatology of The Chinese University of Hong Kong, we developed a special superparamagnetic iron oxide nanoparticle (diameter: approximately10nm) which has very high intracellular labeling efficacy (see attached figure). The labeling procedure is straight forward and no transfection agent is required. Due to its silica coating, the nanoparticle is resistant to the intracellular enzyme and acid, and therefore suitable for long term labeling. The application, among others, includes stem cell labeling for in vivo MRI tracking, inflammation cells (such as macrophages, monocytes) in vivo MRI visualization (therefore as region specific inflammation marker). These superparamagnetic iron oxide nanoparticle can also be used as ex vivo histology marker. Technology support can be provided.

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